解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in a variety of tumor cells, but not most normal cells. Nevertheless, its therapeutic potential is limited due to the frequent occurrence of resistance in tumor cells, especially hepatocellular carcinoma cell lines. Theref...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.21707
更新日期:2017-10-12 00:00:00
abstract::The therapy of breast cancer is encumbered by drug resistance and metastasis, which can be due to a defective PI3K/AKT/mTOR signaling pathway. This study was aimed at improving the anti-cancer effect of the chemotherapeutic agent paclitaxel (PTX) on the drug resistant and metastatic breast cancer by co-delivering PTX ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.21516
更新日期:2017-09-26 00:00:00
abstract::Talazoparib, a potent PARP inhibitor, has shown promising clinical and pre-clinical activity by inducing synthetic lethality in cancers with germline Brca1/2 mutations. Conventional oral delivery of Talazoparib is associated with significant off-target effects, therefore we sought to develop new delivery systems in th...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.18563
更新日期:2017-09-26 00:00:00
abstract::Cancer stem cells (CSCs) are believed to be a principal cellular source for tumour progression and therapeutic drug resistance as they are capable of self-renewal and can differentiate into cancer cells. Importantly, CSCs acquire the ability to evade the killing effects of cytotoxic agents through changes at the genet...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.20725
更新日期:2017-09-13 00:00:00
abstract::Salivary adenoid cystic carcinoma (SACC) is a peculiar malignant tumor, characterized by its slow but inexorable growth, with a high incidence of lung metastasis and poor prognosis. Here, we show the upregulated expression of EGFR ligand epiregulin in a subset of SACC cells correlates with lung metastasis and unfavora...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.19712
更新日期:2017-08-23 00:00:00
abstract::Body fluids are a rich source of extracellular vesicles (EVs), which carry cargo derived from the secreting cells. So far, biomarkers for pathological conditions have been mainly searched from their protein, (mi)RNA, DNA and lipid cargo. Here, we explored the small molecule metabolites from urinary and platelet EVs re...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.19890
更新日期:2017-08-23 00:00:00
abstract::Malignant glioma is one of the most untreatable cancers because of the formidable blood-brain barrier (BBB), through which few therapeutics can penetrate and reach the tumors. Biologics have been booming in cancer therapy in the past two decades, but their application in brain tumor has long been ignored due to the im...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.20578
更新日期:2017-08-15 00:00:00
abstract::Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases. However, the epigenetic mechanisms underlying ferroptosis remain poorly defined. First, we demonstrated that lymphoid-specific helicase (LSH), which is a DNA methylation modifier, interacted with WDR76 to inhibit ferroptosis...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.19988
更新日期:2017-07-23 00:00:00
abstract::The development of nanoscaled theranostic agents for cancer combination therapies has received intensive attention in recent years. In this report, a degradable hollow mesoporous PEG-Si/C-DOX NP is designed and fabricated for pH-responsive, photoacoustic imaging-guided highly effective chemo-thermal combination therap...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.18460
更新日期:2017-07-22 00:00:00
abstract::Ocular neovascularization is a pathological sequel of multiple eye diseases. Based on the anatomical site into which the abnormal neovessels grow, ocular neovascularization can be categorized into corneal neovascularization, choroidal neovascularization, and retinal neovascularization. Each category is intractable, an...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.19646
更新日期:2017-07-22 00:00:00
abstract::The distorted and unique expression of microRNAs (miRNAs) in cancer makes them an attractive source of biomarker. There is much evidence indicating that a panel of miRNAs, termed "miRNA fingerprints", is more specific and informative than an individual miRNA as biomarker. Thus, multiplex assays for simultaneous quanti...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.19113
更新日期:2017-07-08 00:00:00
abstract::A major challenge in photodynamic therapy (PDT) is the development of new tumor-targeting photosensitizers. The tumor-specific activation is considered to be an effective strategy for designing these photosensitizers. Herein, we describe a novel tumor-pH-responsive supramolecular photosensitizer, LDH-ZnPcS8, which is ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.18861
更新日期:2017-07-07 00:00:00
abstract::Circulating tumor cells (CTCs) have shown promising potential as liquid biopsies that facilitate early detection, prognosis, therapeutic target selection and monitoring treatment response. CTCs in most cancer patients are low in abundance and heterogeneous in morphological and phenotypic profiles, which complicate the...
journal_title:Theranostics
pub_type: 杂志文章,评审
doi:10.7150/thno.18588
更新日期:2017-06-25 00:00:00
abstract::Because of the unparalleled efficiency and universal utility in treating a variety of disease types, siRNA agents have evolved as the future drug-of-choice. Yet, the inability of the polyanionic siRNA macromolecules to cross the cell membrane remains as the bottleneck of possible clinical applications. With the cell p...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.19863
更新日期:2017-06-25 00:00:00
abstract::Purpose: Evans Blue (EB) is an azo dye that binds quantitatively with serum albumin. With an albumin binding, NOTA conjugated truncated Evan's blue (NEB) dye derived PET tracer, we aimed to establish a strategy for evaluating vascular permeability in malignant tumors via non-invasive PET. Experimental design: Sixty-mi...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.19898
更新日期:2017-06-14 00:00:00
abstract::Catalytic nanomaterials with intrinsic enzyme-like activities, called nanozymes, have recently attracted significant research interest due to their unique advantages relative to natural enzymes and conventional artificial enzymes. Among the nanozymes developed, particular interests have been devoted to nanozymes with ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.19257
更新日期:2017-06-01 00:00:00
abstract::18F-Fluciclovine (trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid; anti-18F-FACBC) is a positron emission tomography (PET) tracer for diagnosing cancers (e.g., prostate and breast cancer). The most frequent metastatic organ of these cancers is bone. Fluciclovine-PET can visualize bony lesions in clinical practice...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.19883
更新日期:2017-05-15 00:00:00
abstract::Dendritic cells (DC) and tumor cell fusion vaccine (DC/tumor cell fusion vaccine) is considered an effective approach in cancer biotherapy. However, its therapeutic effects in early clinical trials have been suboptimal partially due to the immunosuppressive tumor environment. In this study, we used nanoparticles of fo...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.16236
更新日期:2017-05-02 00:00:00
abstract::Stem cell therapy holds promise for treatment of intractable diseases and injured organs. For clinical translation, it is pivotal to understand the homing, engraftment, and differentiation processes of stem cells in a living body. Here we report near-infrared (NIR) fluorescent semiconductor polymer dots (Pdots) for br...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.18614
更新日期:2017-04-10 00:00:00
abstract::Lung cancer is the leading cause of cancer-related death worldwide. Most targeted drugs approved for lung cancer treatment are tyrosine kinase inhibitors (TKIs) directed against EGFR or ALK, and are used mainly for adenocarcinoma. At present, there is no effective or tailored targeting agent for large cell carcinoma (...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.17573
更新日期:2017-04-10 00:00:00
abstract::Background: By targeting the prostate-specific membrane antigen (PSMA) on prostate cancer (PCa) cells PSMA-PET/CT shows great potential in locating the site of biochemical recurrence even at low PSA (Prostate-specific antigen)-levels. Accurate imaging of PCa recurrent lymph node metastases (LNM) is crucial for metasta...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.18421
更新日期:2017-04-10 00:00:00
abstract::Purpose: Breast cancer imaging methods lack diagnostic accuracy, in particular for patients with dense breast tissue, and improved techniques are critically needed. The purpose of this study was to evaluate antibody-indocyanine green (ICG) conjugates, which undergo dynamic absorption spectrum shifts after cellular end...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.18217
更新日期:2017-04-03 00:00:00
abstract::5-Fluorouracil (5-FU) combined with radiotherapy is a common treatment strategy to treat human cancers, but the underlying mechanisms of this combination treatment remain unclear. Here, we report that NAD+-dependent deacetylase sirtuin-7 (SIRT7) protein levels were decreased due to 5-FU exposure rendering colorectal c...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.18804
更新日期:2017-03-22 00:00:00
abstract::Gold nanoparticles (AuNPs) have been reported to promote osteogenic differentiation of mesenchymal stem cells and osteoblasts, but little is known about their effects on human periodontal ligament progenitor cells (PDLPs). In this study, we evaluated the effects of AuNPs with various diameters (5, 13 and 45 nm) on the...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.17252
更新日期:2017-03-06 00:00:00
abstract::Oral squamous cell carcinoma (OSCC), an epithelial malignancy affecting a variety of subsites in the oral cavity, is prevalent in Asia. The survival rate of OSCC patients has not improved over the past decades due to its heterogeneous etiology, genetic aberrations, and treatment outcomes. Improvement in therapeutic st...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.18551
更新日期:2017-02-26 00:00:00
abstract::Although the prognosis of differentiated thyroid cancer (DTC) is relatively good, 30-40% of patients with distant metastases develop resistance to radioactive iodine therapy due to tumor dedifferentiation. For DTC patients harboring BRAFV600E mutation, Vemurafenib, a BRAF kinase inhibitor, has dramatically changed the...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.17322
更新日期:2017-02-23 00:00:00
abstract::Detection of biomarkers is extremely important for the early diagnosis of diseases. Here, we developed an easy and highly sensitive fluorescence detection system for the determination of biomarkers by combining the rapid separation of magnetic beads and silver nanoparticles labeled antibodies. An ultrasensitive silver...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.17575
更新日期:2017-02-08 00:00:00
abstract::This work reports that when PEG-lipid-shelled microbubbles with fluorocarbon interior (C4F10, C5F12, or C6F14) are subjected to ultrasound pulses, they produce metastable, fluid-filled nanoparticles that can be re-imaged upon administration of HIFU. The nanoparticles produced by destruction of the microbubbles (MBNPs)...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.17522
更新日期:2017-01-15 00:00:00
abstract::[This retracts the article on p. 3 in vol. 1, PMID: 21547151.]. ...
journal_title:Theranostics
pub_type: 杂志文章,撤回出版物
doi:10.7150/thno.18746
更新日期:2017-01-07 00:00:00
abstract::Phenytoin, an antiepileptic drug, has been widely used for wound healing. Inspired by previous studies, phenytoin silver (PnAg), a sparingly soluble silver nanocompound, was synthesized which exhibited good therapeutic efficacy in tissue repair with low toxicity (LD50 >5 g/kg). In vivo studies showed that PnAg could a...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.17073
更新日期:2017-01-05 00:00:00
abstract::Systemic infusion of bone marrow-derived mesenchymal stem cells (BMSCs) has become a promising strategy for disease treatment and tissue regeneration. Strategies to enhance the efficiency of BMSC cell therapy are crucial to promote its clinical application. Here, we aimed to improve BMSC cell therapy by inhibiting the...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.16911
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:The exact detection and delineation of the intraprostatic tumour burden is crucial for treatment planning in primary prostate cancer (PCa). We compared 68Ga-HBED-CC-PSMA PET/CT with multiparametric MRI (mpMRI) for diagnosis and tumour delineation in patients with primary PCa based on slice by slice correlation ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.16638
更新日期:2017-01-01 00:00:00
abstract::Phenylboronic acid (PBA)-mediated tumor targeting nanovector is an attractive strategy for enhancing siRNA delivery and treatment of metastatic cancers. However, its nonspecific binding with various biological membranes containing cis-diol moieties restricts its potential application by systematic administration. Here...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.16855
更新日期:2017-01-01 00:00:00
abstract::Mitochondria in cancer cells maintain a more negative membrane potential than normal cells. Mitochondria are the primary source of cellular reactive oxygen species (ROS), which are necessary for photodynamic therapy. Thus, the strategy of targeting mitochondria can maximize the photodynamic therapeutic efficiency for ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.15433
更新日期:2016-10-01 00:00:00
abstract::Elastin-like polypeptide (ELP)-based drug delivery has been utilized for various applications including cancer therapies for many years. Genetic incorporation of internalization ligands and cell-targeting peptides along with ELP polymer enhanced tumor accumulation and retention time as well as stability and activities...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.16425
更新日期:2016-09-25 00:00:00
abstract::Long term pulmonary exposure to crystalline silica leads to silicosis that manifests progressive interstitial fibrosis, eventually leading to respiratory failure and death. Despite efforts to eliminate silicosis, clinical cases continue to occur in both developing and developed countries. The exact mechanisms of cryst...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.16180
更新日期:2016-09-09 00:00:00
abstract::Overexpression of CD146 has been correlated with aggressiveness, recurrence rate, and poor overall survival in hepatocellular carcinoma (HCC) patients. In this study, we set out to develop a CD146-targeting probe for high-contrast noninvasive in vivo positron emission tomography (PET) and near-infrared fluorescence (N...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.15568
更新日期:2016-08-08 00:00:00
abstract::Developing ultrasensitive contrast agents for the early detection of malignant tumors in liver is highly demanded. Constructing hepatic tumors specific targeting probes could provide more sensitive imaging information but still faces great challenges. Here we report a novel approach for the synthesis of ultra-small Fe...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.14280
更新日期:2016-07-15 00:00:00
abstract::Bacteria-based anticancer therapies aim to overcome the limitations of current cancer therapy by actively targeting and efficiently removing cancer. To achieve this goal, new approaches that target and maintain bacterial drugs at sufficient concentrations during the therapeutic window are essential. Here, we examined ...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.16135
更新日期:2016-06-20 00:00:00
abstract::Smart drug delivery system with strategic drug distribution is the future state-of-the-art treatment for any malignancy. To investigate therapeutic potential of such nanoparticle mediated delivery system, we examined the efficacy of dual drug-loaded, pH and thermo liable lipid coated mesoporous iron oxide-based magnet...
journal_title:Theranostics
pub_type: 杂志文章
doi:10.7150/thno.15231
更新日期:2016-06-18 00:00:00